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Ongoing in the ICU setting. There are also case reports with a combination of a new monoclonal antibody against Candida spp (including fluconazoleresistant species), Efungumab, with other antifungals in invasive candidiasis [71,72]. However, no large scale studies are published at this time.Combination antifungal therapyData supporting the routine use of antifungal combinations for invasive candi
The combination of two agents (voriconazole plus echinocandin) is currentlyZafrani and Azoulay BMC Infectious Diseases 2014, 14:512 7 ofrecommended only in salvage therapy for pulmonary aspergillosis. However, an unpublished trial has proven no benefit of combination of antifungal therapy. The combination of caspofungin plus voriconazole is also a tr
G investigated. However, to date, published data are very scarce. New azole antifungals include Ravuconazole, Isavuconazole and Albaconazole. The spectrum of activity of these 3 drugs, based on in vitro studies, include Candida spp. (including fluconazole-resistant isolates), Aspergillus spp and Cryptococcus neoformans [69,70]. Ongoing clinical trials involve the treatment of invasive aspergillos
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