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Nducing IFN- and IFNinduced genes downstream of Toll-like receptor (TLR) activation. Additionally they play prominent role in cytokine secretion, cellular apoptosis, immune cell development, tumor suppression, and cell activation and differentiation [38, 39]. Interestingly, genetic variations in three of the nine IRFs (IRF5, IRF7, and IRF8) have been linked to SLE susceptibility, supporting a key
Ophtheirus salmonis) and in whole-body louse homogenate. J Parasitol 2000, 86(6):1199?205. Jones SRM: The occurrence and mechanisms of innate immunity against parasites in fish. Dev Comp Immunol 2001, 25(8?):841?52. Jones SRM, Fast MD, Johnson SC, Groman DB: Differential rejection of salmon lice by pink and chum salmon: disease consequences and expression of proinflammatory genes. Dis Aquat Organ
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